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Methadone, sold under the brand name Dolophine among others, is an opioid used for opioid maintenance therapy in opioid dependence, and for pain.Detoxification using methadone can either be done relatively rapidly in less than a month or gradually over as long as six months.While a single dose has a rapid effect, maximum effect can take five days of use.The pain relieving effects last about six hours after a single dose, similar to morphine’s.After long term use, in people with normal liver function, effects last 8 to 36 hours.Methadone is usually taken by mouth and rarely by injection into a muscle or vein.Side effects are similar to those of other opioids.Commonly these include dizziness, sleepiness, vomiting, and sweating.Serious risks include opioid abuse and a decreased effort to breathe.Abnormal heart rhythms may also occur due to a prolonged QT interval.The number of deaths in the United States involving methadone poisoning declined from 4,418 in 2011 to 3,300 in 2015.Risks are greater with higher doses.Methadone is made by chemical synthesis and acts on opioid receptors.Methadone was developed in Germany around 1937 to 1939 by Gustav Ehrhart and Max Bockmühl.It was approved for use in the United States in 1947.Methadone is on the World Health Organization’s List of Essential Medicines, the most effective and safe medicines needed in a health system.Globally in 2013, about 41,400 kilograms were manufactured.It is regulated similarly to other narcotic drugs.It is not particularly expensive in the United States.Methadone is used for the treatment of opioid use disorder. It may be used as a maintenance therapy or in shorter periods for detoxification to manage opioid withdrawal symptoms.Buy Methadone 10mg Tablet Online
A 2009 Cochrane review found methadone was effective in retaining people in treatment and in the reduction or cessation of heroin use as measured by self-report and urine/hair analysis but did not affect criminal activity or risk of death.Treatment of opioid-dependent persons with methadone follow one of two routes, maintenance or detoxification.Methadone maintenance therapy (MMT) usually takes place in outpatient settings. It is usually prescribed as a single daily dose medication for those who wish to abstain from illicit opioid use. Treatment models for MMT differ. It is not uncommon for treatment recipients to be administered methadone in a specialist clinic, where they are observed for around 15–20 minutes post dosing, to reduce risk of diversion of medication.The duration of methadone treatment programs range from a few months to several years. Given opioid dependence is characteristically a chronic relapsing/remitting disorder, MMT may be lifelong. The length of time a person remains in treatment depends on a number of factors. While starting doses may be adjusted based on the amount of opioids reportedly used, most clinical guidelines suggest doses start low (e.g. at doses not exceeding 40 mg daily) and are incremented gradually.Methadone maintenance has been shown to reduce the transmission of blood borne viruses associated with opioid injection, such as hepatitis B and C, and/or HIV.The principal goals of methadone maintenance are to relieve opioid cravings, suppress the abstinence syndrome, and block the euphoric effects associated with opioids.Chronic methadone dosing will eventually lead to neuroadaptation, characterised by a syndrome of tolerance and withdrawal (dependence). However, when used correctly in treatment, maintenance therapy has been found to be medically safe, non-sedating, and can provide a slow recovery from opioid addiction.Methadone has been widely used for pregnant women addicted to opioids.Methadone is use to treats moderate to severe pain. Also used together with medical supervision and cancelling for treatment of narcotic drug addiction. This medicine is a narcotic pain reliever.Methadone is a prescription drug. It’s an opioid, which makes it a controlled substance. That means its use will be closely monitored by your doctor.Methadone comes as an oral tablet.Methadone is also used to manage drug addiction. If you’re addicted to another opioid, your doctor may give you methadone to prevent you from having severe withdrawal symptoms.Methadone is approved in the US, and many other parts of the world, for the treatment of opioid addiction. Its use for the treatment of addiction is usually strictly regulated. In the US, outpatient treatment programs must be certified by the federal Substance Abuse and Mental Health Services Administration (SAMHSA) and registered by the Drug Enforcement Administration (DEA) in order to prescribe methadone for opioid addiction.Methadone is used as an analgesic in chronic pain, often in rotation with other opioids.Due to its activity at the NMDA receptor, it may be more effective against neuropathic pain; for the same reason, tolerance to the analgesic effects may be less than that of other opioids.
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