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Buy Methylenedioxypyrovalerone (MDPV) Powder Online

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Buy Methylenedioxypyrovalerone (MDPV) Powder Online

$310.00$1,800.00

Methylenedioxypyrovalerone (MDPV) is a stimulant of the cathinone class which acts as a Norepinephrine–dopamine reuptake inhibitor (NDRI)

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Buy Methylenedioxypyrovalerone (MDPV) Powder Online

Methylenedioxypyrovalerone (MDPV) is a stimulant of the cathinone class which acts as a Norepinephrine–dopamine reuptake inhibitor (NDRI) Buy Methylenedioxypyrovalerone (MDPV) Powder Online It was first developed in the 1960s by a team at Boehringer Ingelheim.Its activity at the dopamine transporter is six times stronger than at the norepinephrine transporter and it is virtually inactive at the serotonin transporter.MDPV remained an obscure stimulant until around 2004 Buy Methylenedioxypyrovalerone (MDPV) Powder Online,when it was reportedly sold as a designer drug. Until banned in 2011, products containing MDPV and labeled as bath salts were sold as recreational drugs in gas stations and convenience stores in the United States, similar to the marketing for Spice and K2 as incense.Buy Methylenedioxypyrovalerone (MDPV) Powder Online.It was first developed in the 1960s by a team at Boehringer Ingelheim.Buy Methylenedioxypyrovalerone (MDPV) Powder Online. It was first developed in the 1960s by a team at Boehringer Ingelheim.Its activity at the dopamine transporter is six times stronger than at the norepinephrine transporter and it is virtually inactive at the serotonin transporter.MDPV remained an obscure stimulant until around 2004 when it was reportedly sold as a designer drug. Until banned in 2011, products containing MDPV and labeled as bath salts were sold as recreational drugs in gas stations and convenience stores in the United States, similar to the marketing for Spice and K2 as incense.Buy Methylenedioxypyrovalerone (MDPV) Powder OnlineThe hydrochloride salt exists as a very fine crystalline powder; it is hygroscopic and thus tends to form clumps, resembling something like powdered sugar. Its color can range from pure white to a yellowish-tan and has a slight odor that strengthens as it colors. Impurities are likely to consist of either pyrrolidine or alpha-dibrominated alkylphenones—respectively, from either excess pyrrolidine or incomplete amination during synthesis. These impurities likely account for its discoloration and fishy (pyrrolidine) or bromine-like odor, which worsens upon exposure to air, moisture, or bases.Methylenedioxypyrovalerone has no record of FDA approved medical use.It has been shown to produce robust reinforcing effects and compulsive self-administration in rats, though this had already been provisionally established by a number of documented cases of misuse and addiction in humans before the animal tests were carried out.MDPV is the 3,4-methylenedioxy ring-substituted analog of the compound pyrovalerone, developed in the 1960s, which has been used for the treatment of chronic fatigue and as an anorectic, but caused problems of abuse and dependence.Other drugs with a similar chemical structure include α-pyrrolidinopropiophenone (α-PPP), 4′-methyl-α-pyrrolidinopropiophenone (M-α-PPP), 3′,4′-methylenedioxy-α-pyrrolidinopropiophenone (MDPPP) and 1-phenyl-2-(1-pyrrolidinyl)-1-pentanone (α-PVP).MDPV acts as a stimulant and has been reported to produce effects similar to those of cocaine, methylphenidate, and amphetamines.Buy Methylenedioxypyrovalerone (MDPV) Powder Online.The primary psychological effects have a duration of roughly 3 to 4 hours, with aftereffects such as tachycardia, hypertension, and mild stimulation lasting from 6 to 8 hours.High doses have been observed to cause intense, prolonged panic attacks in stimulant-intolerant users,and there are anecdotal reports of psychosis from sleep withdrawal and addiction at higher doses or more frequent dosing intervals.It has also been repeatedly noted to induce irresistible cravings to re-administer.Reported modalities of intake include oral consumption, insufflation, smoking, rectal and intravenous use. It is supposedly active at 3–5 mg, with typical doses ranging between 5–20 mg.When assayed in mice, repeated exposure to MDPV caused not only an anxiogenic effect but also increased aggressive behavior, a feature that had already been seen in humans. As with MDMA, animals adapted faster to the repeated social isolation. Additionally, a bidirectional cross-sensitization between MDPV and cocaine was evidenced.The long-term effects of MDPV on humans have not been studied, but it has been reported that mice treated with MDPV during adolescence show reinforcing behavior patterns to cocaine that are higher than the control group’s. These behavioural changes are related to alterations of factor expression directly related to addiction. All this suggests an increased vulnerability to cocaine abuse.MDPV undergoes CYP450 2D6, 2C19, 1A2,[16] and COMT phase 1 metabolism (liver) into methylcatechol and pyrrolidine, which in turn are glucuronated (uridine 5′-diphospho-glucuronosyl-transferase) allowing it to be excreted by the kidneys, with only a small fraction of the metabolites being excreted into the stools.No free pyrrolidine will be detected in the urine.Molecularly, this is seen as demethylenation of methylenedioxypyrovalerone (CYP2D6), followed by methylation of the aromatic ring via catechol-O-methyl transferase. Hydroxylation of both the aromatic ring and side chain then takes place, followed by an oxidation of the pyrrolidine ring to the corresponding lactam, with subsequent detachment and ring opening to the corresponding carboxylic acid.Buy Methylenedioxypyrovalerone (MDPV) Powder Online

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