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Morphine is use to treats moderate to severe pain. Also used together with medical supervision and counseling for treatment of narcotic drug addiction.Buy Morphine 60mg Tablet Online.
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Morphine is a pain medication of the opiate family which is found naturally in a number of plants and animals.It acts directly on the central nervous system (CNS) to decrease the feeling of pain.It can be taken for both acute pain and chronic pain.It is frequently used for pain from myocardial infarction and during labour.It can be given by mouth, by injection into a muscle, by injection under the skin, intravenously, injection into the space around the spinal cord, or rectally.Maximum effect is reached after about 20 minutes when given intravenously and after 60 minutes when given by mouth, while duration of effect is 3–7 hours.Long-acting formulations also exist.Potentially serious side effects include decreased respiratory effort and low blood pressure.Morphine is addictive and prone to abuse.If the dose is reduced after long-term use, opioid withdrawal symptoms may occur.Common side effects include drowsiness, vomiting, and constipation.Caution is advised when used during pregnancy or breast feeding, as morphine may affect the baby.Morphine was first isolated between 1803 and 1805 by Friedrich Sertürner.This is generally believed to be the first isolation of an active ingredient from a plant.Merck began marketing it commercially in 1827.Morphine was more widely used after the invention of the hypodermic syringe in 1853–1855.Sertürner originally named the substance morphium after the Greek god of dreams, Morpheus, as it has a tendency to cause sleep.The primary source of morphine is isolation from poppy straw of the opium poppy.In 2013, approximately 523 tons of morphine were produced.Approximately 45 tons were used directly for pain, a four-fold increase over the last twenty years.Most use for this purpose was in the developed world.About 70 percent of morphine is used to make other opioids such as hydromorphone, oxymorphone, and heroin.It is a Schedule II drug in the United States,Class A in the United Kingdom,and Schedule I in Canada.It is on the World Health Organization’s List of Essential Medicines, the most effective and safe medicines needed in a health system.Morphine is sold under many trade names.In 2016, it was the 158th most prescribed medication in the United States, with more than 3 million prescriptions.Morphine is use to treats moderate to severe pain. Also used together with medical supervision and counseling for treatment of narcotic drug addiction. This medicine is a narcotic pain reliever.Methadone is a prescription drug. It’s an opioid, which makes it a controlled substance. That means its use will be closely monitored by your doctor.Methadone comes as an oral tablet.Morphine is also used to manage drug addiction. If you’re addicted to another opioid, your doctor may give you Morphine to prevent you from having severe withdrawal symptoms.Morphine is used primarily to treat both acute and chronic severe pain. It is also used for pain due to myocardial infarction and for labor pains.Its duration of analgesia is about three to seven hours.
However, concerns exist that morphine may increase mortality in the event of non ST elevation myocardial infarction.Morphine has also traditionally been used in the treatment of acute pulmonary edema.A 2006 review, though, found little evidence to support this practice.A 2016 Cochrane review concluded that morphine is effective in relieving cancer pain. Side-effects of nausea and constipation are rarely severe enough to warrant stopping treatment.Morphine is beneficial in reducing the symptom of shortness of breath due to both cancer and noncancer causes.In the setting of breathlessness at rest or on minimal exertion from conditions such as advanced cancer or end-stage cardiorespiratory diseases, regular, low-dose sustained-release morphine significantly reduces breathlessness safely, with its benefits maintained over time.Morphine is also available as a slow-release formulation for opiate substitution therapy (OST) in Austria, Bulgaria, and Slovenia, for addicts who cannot tolerate either methadone or buprenorphine.Relative contraindications to morphine include:respiratory depression when appropriate equipment is not available,Buy Morphine 60mg Tablet Online,Order Morphine 60mg Tablet Online
Although it has previously been thought that morphine was contraindicated in acute pancreatitis, a review of the literature shows no evidence for this.Like loperamide and other opioids, morphine acts on the myenteric plexus in the intestinal tract, reducing gut motility, causing constipation. The gastrointestinal effects of morphine are mediated primarily by opioid receptors in the bowel. By inhibiting gastric emptying and reducing propulsive peristalsis of the intestine, morphine decreases the rate of intestinal transit. Reduction in gut secretion and increased intestinal fluid absorption also contribute to the constipating effect.Buy Morphine 60mg Tablet Online Opioids also may act on the gut indirectly through tonic gut spasms after inhibition of nitric oxide generation.This effect was shown in animals when a nitric oxide precursor, L-arginine, reversed morphine-induced changes in gut motility.Clinical studies consistently conclude that morphine, like other opioids, often causes hypogonadism and hormone imbalances in chronic users of both sexes. This side effect is dose-dependent and occurs in both therapeutic and recreational users. Morphine can interfere with menstruation in women by suppressing levels of luteinizing hormone. Many studies suggest the majority (perhaps as many as 90%) of chronic opioid users have opioid-induced hypogonadism. This effect may cause the increased likelihood of osteoporosis and bone fracture observed in chronic morphine users. Studies suggest the effect is temporary. As of 2013, the effect of low-dose or acute use of morphine on the endocrine system is unclear.Most reviews conclude that opioids produce minimal impairment of human performance on tests of sensory, motor, or attentional abilities. However, recent studies have been able to show some impairments caused by morphine, which is not surprising, given that morphine is a central nervous system depressant. Morphine has resulted in impaired functioning on critical flicker frequency (a measure of overall CNS arousal) and impaired performance on the Maddox wing test (a measure of the deviation of the visual axes of the eyes). Few studies have investigated the effects of morphine on motor abilities; a high dose of morphine can impair finger tapping and the ability to maintain a low constant level of isometric force (i.e. fine motor control is impaired),though no studies have shown a correlation between morphine and gross motor abilities.In terms of cognitive abilities, one study has shown that morphine may have a negative impact on anterograde and retrograde memory,but these effects are minimal and transient. Overall, it seems that acute doses of opioids in non-tolerant subjects produce minor effects in some sensory and motor abilities, and perhaps also in attention and cognition. It is likely that the effects of morphine will be more pronounced in opioid-naive subjects than chronic opioid users.In chronic opioid users, such as those on Chronic Opioid Analgesic Therapy (COAT) for managing severe, chronic pain, behavioural testing has shown normal functioning on perception, cognition, coordination and behaviour in most cases. One 2000 study analysed COAT patients to determine whether they were able to safely operate a motor vehicle. The findings from this study suggest that stable opioid use does not significantly impair abilities inherent in driving (this includes physical, cognitive and perceptual skills). COAT patients showed rapid completion of tasks that require the speed of responding for successful performance (e.g., Rey Complex Figure Test) but made more errors than controls. COAT patients showed no deficits in visual-spatial perception and organization (as shown in the WAIS-R Block Design Test) but did show impaired immediate and short-term visual memory (as shown on the Rey Complex Figure Test – Recall). These patients showed no impairments in higher-order cognitive abilities (i.e., planning). COAT patients appeared to have difficulty following instructions and showed a propensity toward impulsive behaviour, yet this did not reach statistical significance. It is important to note that this study reveals that COAT patients have no domain-specific deficits, which supports the notion that chronic opioid use has minor effects on psychomotor, cognitive, or neuropsychological functioning.Buy Morphine 60mg Tablet Online,Order Morphine 60mg Tablet Online
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